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    Home»Development»Machine Learning»Addressing Misspecification in Simulation-based Inference through Data-driven Calibration

    Addressing Misspecification in Simulation-based Inference through Data-driven Calibration

    July 8, 2025

    Driven by steady progress in deep generative modeling, simulation-based inference (SBI) has emerged as the workhorse for inferring the parameters of stochastic simulators. However, recent work has demonstrated that model misspecification can compromise the reliability of SBI, preventing its adoption in important applications where only misspecified simulators are available. This work introduces robust posterior estimation~(RoPE), a framework that overcomes model misspecification with a small real-world calibration set of ground-truth parameter measurements. We formalize the misspecification…

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